Persistent infections caused by Staphylococcus aureus remain a clinical challenge.Adaptational mechanisms of the pathogen influencing infection persistence, treatment success, and clinical outcome in these types of infections by S.aureus have not been fully elucidated so far.We applied a whole-genome sequencing approach on fifteen isolates retrieve
Valorisation of Three Underutilised Native Australian Plants: Phenolic and Organic Acid Profiles and In Vitro Antimicrobial Activity
Tasmannia lanceolata, Diploglottis bracteata and Syzygium aqueum are understudied native Australian plants.This study aimed to characterise the non-anthocyanin phenolic and organic acid profiles of the aqueous extracts obtained from the leaves of T.lanceolata and fruits of D.bracteata and S.aqueum by UHPLC-Q-Orbitrap-MS/MS and UHPLC-TQ-MS/MS.A tota
The Revival of the Notes Field: Leveraging the Unstructured Content in Electronic Health Records
Problem: Clinical practice requires the production of a time- and resource-consuming great amount of notes.They contain relevant information, but their secondary use is almost impossible, due to their unstructured nature.Researchers are trying to address this problems, with traditional and promising novel techniques.Application in real hospital set
Identification of Ftr1 and Zrt1 as iron and zinc micronutrient transceptors for activation of the PKA pathway in Saccharomyces cerevisiae
Multiple types of nutrient transceptors, membrane proteins that combine a transporter and receptor function, have now been established in a variety of organisms.However, so far all established transceptors utilize one of the macronutrients, glucose, amino acids, ammonium, nitrate, phosphate or sulfate, as substrate.This is also true for the Sacchar
Development, clinical utility, and place in therapy of posaconazole for prevention and treatment of invasive fungal infections
Emily Zoller, Connie Valente, Kyle Baker, Michael E KlepserFerris State University College of Pharmacy, Kalamazoo, Michigan, USAAbstract: Posaconazole is an extended-spectrum azole antifungal that exhibits activity against a broad range of fungal pathogens, including yeasts and moulds.Clinical data have demonstrated the clinical utility of posacona